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    Common name

    Ampicillin Sodium and Sulbactam Sodium for Injection

    Product name Unasyn®
    Common name

    Ampicillin Sodium and Sulbactam Sodium for Injection

    Product manufacturer

    HAUPT PHARMA LATINA S.R.L. (Pfizer Limited)

    Product approval

    H20160571

    Indication

    UNASYN® is indicated for the treatment of upper respiratory tract infection, urinary tract infection, peritonitis, cholecystitis, endometritis, pelvic cellulitis, septicemia, skin and soft tissue infection, bone and joint infection and gonococcal infection due to susceptible strains of the designated microorganisms. It is also used for surgical infection and prophylaxis.

    Specification

      0.75g (containing 0.50g ampicillin and 0.25g sulbactam)

    Dosage

    Deep intramuscular injection, intravenous injection or intravenous drip.  Dissolve each dose in 50-100 ml of appropriate diluent for intravenous drip within 15-30 minutes.  For adults, 1.5-12g/day, one injection every 6-8hr.  For children (<30kg), the dose is 150mg/kg weight/day, one injection every 6-8hr.  For patients with serious renal impairment, the dose should be reduced. 



    Pharmacological action and purpose: 

    This product is a methylene linked diester of β -lactamase inhibitor sulbactam and semisynthetic penicillin ampicillin, is easy to absorb in gastrointestinal tract and is rapidly hydrolyzed into sulbactam and ampicillin by esterase in vivo, with a bioavailability of 80%.  Sulbactam is a broad spectrum β -lactamase inhibitor, which has a strong inhibitory effect on β -lactamase produced by Staphylococcus aureus and most negative bacilli, but β -lactamase mediated by chromosomes in some negative bacilli is not easy to be inhibited by sulbactam.  The two components in the serum have good synergistic antibacterial effect, which greatly improves the antibacterial activity of ampicillin. This product has the same antibacterial spectrum as that of ampicillin, but its antibacterial strength has been greatly improved.  It is mainly used for respiratory system infection caused by staphylococcus aureus, staphylococcus epidermidis, pneumococcus, streptococcus faecalis, Bacillus influenzae, bacillus parainfluenza and Branhamella catarhalis, and has good curative effect on infection caused by Escherichia coli, Klebsiella pneumoniae and Proteus. 


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